Our research is at the intersection of
biology + computer science + statistics + applied mathematics
The Krishnan lab develops and applies computational approaches to find explanations for how our genome relates to various aspects of health and disease.
We use statistics and machine learning to analyze large-scale data and build genome-scale predictive models about the genetic basis of biomedical phenomena.
We frequently work with experimental and clinical researchers to motivate our methods and put our computational models/predictions to test in human and model systems.
Our overarching goal is two-fold:
Gain more nuanced and accurate insights into the genes and networks underlying physiology, complex diseases, and clinical phenotypes, and
Use these insights to mechanistically link an individual's genomic profiles to a precise assessment of her/his physiological/clinical traits, risks, and outcomes.
[* Joint primary author] [† Corresponding author]
Understanding multi-cellular function and disease with human tissue-specific gene interaction networks.
Greene CS*, Krishnan A*, Wong AK*, Ricciotti E, Zelaya R, Himmelstein D, Chasman D, Fitzgerald G, Dolinski K, Grosser T, Troyanskaya OG.
Nature Genetics (2015) 47:569-576. doi:10.1038/ng.3259
[pubmed] [commentary: nature biotechnology]
Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder.
Krishnan A*, Zhang R*, Yao V, Theesfeld CL, Wong AK, Tadych A, Volfovsky N, Packer A, Lash A, Troyanskaya OG.
Nature Neuroscience (2016) 19:1454-1462. doi:10.1038/nn.4353
[bioRxiv] [pubmed] [commentary: science]
[press: princeton | simons foundation | popular science | researchgate]
Ingo Braasch, Michigan State U. | Keith English, Michigan State U. | Julia Ganz, Michigan State U. | Santhosh Girirajan, Penn State U. | Kelly Klump, Michigan State U. | Rick Leach, Michigan State U. | Adam Moeser, Michigan State U. | Andy Pereira, U. Arkansas | Dhandapany Perundurai, OHSU | Aaditya Rangan, New York U. | Olga Troyanskaya, Princeton U.
Computational genomics and biomedical data science
Applied statistical and machine learning
Integrative analysis of large-scale genomics / biomedical data
Genome-wide molecular interaction networks
Age-specificity & sex differences in health and disease
Cross-species models for human traits and diseases
Genetic heterogeneity of complex disease and precision medicine
Dept. Biochemistry and Molecular Biology at MSU